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Sunday, May 23, 2010

The Science Behind Resveratrol

Resveratrol – a compound, which is similar in its structure to a flavonoid from the Vitamin C family of compounds
– is found in grapes, cranberries, blueberries, peanuts,
rhubarb, and other plant species. It is a protective antioxidant
molecule* produced in these plants as a result
of stress, such as fungal invasion, injury, oxidative
damage, and ultraviolet radiation. Like flavonoids, resveratrol
is a potent antioxidant; but it is also a unique
molecule that has significant anti-aging effects.*
Researchers are studying the effects of reducing
calorie intake on lifespan, and numerous studies now
show caloric restriction appears to lengthen lifespan
in many species.

Resveratrol supplementation has been shown to mimic
the effects of caloric restriction,*
increasing the lifespan of numerous species,
including yeast, roundworms, fruit flies, and mice. In
studies in which mice were fed either a high-calorie
diet, a low-calorie diet, or a high-calorie diet with
resveratrol, the resveratrol-supplemented high-calorie
group did not exhibit some of the adverse metabolic
effects associated with this diet.

The resveratrol-supplemented mice were more
insulin sensitive, did not develop fatty liver,
and lived longer. The resveratrol fed
mice also had improved muscle function, and in
one study the mice did not gain weight.

Resveratrol appears to work by activating specific genes that
result in modulation of cellular activity, including
up-regulation of the SIRT-1 enzyme, which acts as a
cellular switch that supports mitochondrial function
and increases the number of mitochondria in each
cell.* An increase in cellular mitochondria results in
more efficient energy production within the cell and
may relate to more efficient fat metabolism and increased

SIRT-1 also is involved in blood glucose regulation, insulin
sensitivity, and cell survival.*

Its impact on the SIRT-1 enzyme is just one of many
cellular effects resveratrol has on the body. Resveratrol
also modulates the activity of cellular transcription
factors like NF-κB, which helps regulate the
body’s normal inflammatory response, cell proliferation,
and immune activity.*

Resveratrol supports cardiovascular function via its antioxidant activity and by increasing the activity of endothelial nitric oxide
synthase (eNOS), thus increasing the production of nitric oxide in vascular endothelial cells.*

This results in healthier blood vessels, better regulation of vasodilation
and blood flow, and decreased adhesion of inflammatory cells in blood vessels.*
Resveratrol is considered by some researchers to be
the molecule in red wine that explains the “French
Paradox,” an epidemiological observation that the
French, who eat more saturated fat and drink more
alcohol than citizens of many other countries, have
a lower risk of cardiovascular disease. Resveratrol’s
support of the body’s normal inflammatory response
and its health-promoting effects in blood vessels may
partly explain this observation.*

Quick Absorption and Rapid Metabolism*

When a resveratrol supplement is ingested it is quickly
absorbed from the small intestine; then, after reaching
the liver, sulfur or a glucuronic acid molecule
attaches to the resveratrol, which inactivates it. This
rapid metabolism of resveratrol has caused researchers
to doubt whether resveratrol taken orally results
in high enough blood levels to have the effects in the
body that have been seen in numerous in vitro and
animal studies.

PolyResveratrol- SR is the only resveratrol supplement
with synergistic botanicals and metabolites in a time-release matrix.


Pure Resveratrol with Botanicals and a Synergistic Metabolite
PolyResveratrol-SR contains 100% trans-resveratrol,
not an extract that is 50% or less resveratrol.

PolyResveratrol-SR contains pure trans-pterostilbene,
a naturally-occurring methylated metabolite of resveratrol
that appears to be better absorbed than resveratrol
and is not as easily broken down in the liver.*

Animal and in vitro studies show pterostilbene has
anti-aging effects similar to resveratrol* but reaches
higher blood levels and is longer lasting in the body.

The flavonoid quercetin has a positive effect on
resveratrol metabolism. Research has shown quercetin
not only slows the breakdown of resveratrol in
the body, it also acts as a potent antioxidant and is
synergistic with the activities of resveratrol.* PolyResveratrol-
SR contains Thorne’s patented water-soluble quercetin for better absorption.

Studies show curcumin supports the body’s normal
inflammatory response, promotes liver detoxification,
and demonstrates synergistic anti-aging activity
with resveratrol.* In fact, curcumin and resveratrol
given together resulted in a 15% greater antioxidant
effect than either given separately.*

PolyResveratrol-SR contains the Curcumin Phytosome Meriva, which
is significantly better absorbed than a standardized
curcumin extract.*

Green Tea Phytosome has a positive effect on fat
metabolism, promotes optimal liver detoxification, is
a potent antioxidant, and is highly absorbed.* These
properties and others allow green tea polyphenols,
including EGCG, to work synergistically with the
activities of resveratrol.

These synergistic substances in PolyResveratrol-SR
optimize the metabolism and utilization of resveratrol
and enhance its numerous metabolic, cardioprotective,
hepatoprotective ( Liver protecting), and anti-aging properties.*

The Science of Time-Sorb®

PolyResveratrol-SR’s unique formulation is in
Thorne Research’s patent-pending time-release
matrix (Time-Sorb) that promotes higher and more
consistent blood levels of the ingredients over time.

Supplement Facts

Serving Size: Two Capsules Servings per Container: 30
Two Capsules Contain:
Trans Resveratrol** 100 mg.
Trans Pterostilbene** 100 mg.
Curcumin Phytosome (Curcuma longa extract (root)
/ Phosphatidylcholine complex) 100 mg.
Green Tea Phytosome (Camellia sinensis extract (leaf)
/ Phosphatidylcholine complex) 100 mg.
Quercetin (soluble)*** 100 mg.
Other Ingredients: High and low viscosity hydroxypropyl
methyl-cellulose and MagnesiumCitrateLaurate (Time-
Sorb†), Hypromellose (derived from cellulose) capsule,
Leucine, Silicon Dioxide.

†The ingredients in this product are complexed with Time-
Sorb® (Time-Sorb is a patent-pending, time release matrix).
**Thorne’s resveratrol and pterostilbene are 100% materials.
***Water-soluble Quercetin protected under U.S. Patent No.
5,977,184 for Quercetin Chalcone.

Meriva® (Curcumin Phytosome) and Greenselect® (Green Tea Phytosome) are
registered trademarks owned by Indena S.p.A.

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