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Wednesday, February 24, 2010

What is ADMA?

What is ADMA?

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ADMA (asymmetric dimethylarginine) regulates rates of nitric oxide (NO) formation. Since nitric oxide is so important to blood vessel
tension, it is key in the regulation of blood pressure and blood flow to organs.
Why measure ADMA?
Because independent studies have shown that ADMA:
• Is a better predictor of insulin resistance than any other single
• Is a better predictor of vascular endothelial impairment than
• Mediates adverse responses to homocysteine, a risk factor for
cardiovascular disease.
• Mediates cardiovascular effects of cigarette smoking.
• Is highly correlated with serum triglyceride levels. Triglyceride is a
form of fat that can indicate high total cholesterol levels when high.
The Metametrix ADMA Profile is a unique, independent marker of
NO competence and a cost-effective addition to any cardiovascular risk
assessment. The ADMA profile is also included with the Metametrix
Metabolic Syndrome Profile!
Elevated ADMA is a risk factor for:
• Hypertension
• Cardiovascular disease
• Renal failure
• Erectile dysfunction
• Insulin resistance and metabolic
• Diabetes
Factors contributing to ADMA levels:
• Increased oxidative challenge
• Folic acid insufficiency
• Lifestyle habits
• Dietary glycemic index
• Body mass index
• Dietary sucrose intake
• Smoking
• Hormone levels
• Protein intake
Interventions to lower ADMA:
• Increase exercise
• Reduce oxidant stress
• Increase antioxidant levels
• Normalize folic acid, vitamin B12 and
vitamin B6 in Methyl- Guard

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